Understanding Chelating Agents: Properties, Applications, and Uses

Chelating agent is chemical compounds. It can react with metal ions to form a stable, water-soluble complex. You maybe know them as chelants, chelators, or sequestering agents.

Chelating agents have a ring-like center. The ring-like core forms at least two bonds with the metal ion. This structure allows it to be excreted.

Generally, chelating agents are organic compounds. Exactly speaking, a containing carbon compound. Specific chelating agents bind iron, lead, or copper in the blood and can be used to treat excessively high levels of these metals. You must have heard the Chelating therapy. Because the chelating agents can also be used in the treatment of heavy metal poisoning.

OK, I have to repeat the chelating agents define again in that you can understand what exactly it is.

What do chelating agents mean? A chelating agent is a chemical compound that reacts with metal ions to form stable, water-soluble metal complexes.

The agent rearranges the metal's chemical composition and improves the metal's general stability and likelihood to bond with other substances.Chelating agents are used in several applications, including:Medical, Scale removal,Water treatment,Corrosion control.Chelating agents are also known as chelants, chelators or sequestering agents.

What is the chelating agent?

Chelating agent is chemical compounds. It can react with metal ions to form a stable, water-soluble complex. You maybe know them as chelants, chelators, or sequestering agents.

Chelating agents have a ring-like center. The ring-like core forms at least two bonds with the metal ion. This structure allows it to be excreted.

OK, I have to repeat the chelating agents define again in that you can understand what exactly it is.

What do chelating agents mean? A chelating agent is a chemical compound that reacts with metal ions to form stable, water-soluble metal complexes.

The chelating agent's molecules form several bonds to a metal ion and prevent the metal from reacting as it would normally. The bonding to the metal ions re-organizes the ions' core structure and chemical composition. The chemical structures in many metals closely resemble chains. The chelators join the ends of these chain-like structures to form a stable ring, which can move easily through various environments.

Chelating agents are used for:Scale removal and prevention,Breaking down, isolating or moving heavy metal ions,Deactivating metal ions to prevent plugging, sealing and precipitation,Limiting available metal ion concentration,Controlling heavy metal poisoning and reducing metal's toxic effects,Corrosion inhibitors to form insoluble surface chelates.

Chelating agents are either natural or synthetic organic compounds, used for industrial, medical and biological applications. They help in the digestion processes, both in humans and animals, in addition to transporting nutrients in plants. Chelating agents are used in boilers to dissolve common types of scale during normal operation, and provide effective online and offline scale removal in boilers. The surface active chelating agents are used as corrosion inhibitors to form insoluble surface chelates (compounds comprising of the chelating agent and the metal ion).Even though chelating agents can be used for corrosion control, the formation of soluble chelates may provoke stimulation of a corrosion process. Uncontrolled agent application may lead to chelant corrosion. This can be prevented by applying the precise amount that does not leave residuals in the boiler.

A chemical compound that binds tightly to metal ions. In medicine, chelating agents are used to remove toxic metals from the body. They are also being studied in the treatment of cancer.

Chelating agents are used to reduce blood and tissue levels of injurious heavy metals. Chelating agents are generally classified based upon the target heavy metal – iron, copper, mercury and lead being the major targets. Some chelating agents have a high degree of specificity for the target metal, while others chelate multiple agents. Specificity is important in regard to safety, as chelation of other metals or minerals may lead to serious side effects, for instance, lowering of calcium or phosphate levels as occurs with EDTA. The most important step in management of excessive heavy metal accumulation or poisoning is to avoid or eliminate the source of the exposure. Pharmacological interventions are complementary, but are effective and can be life saving.

The iron chelating agents currently in use include deferoxamine, deferasirox and deferiprone, all of which are highly specific for iron and have little or no effect on levels of copper, lead, calcium, magnesium or phosphate. Deferasirox and deferiprone can be administered orally, whereas deferoxamine requires parenteral administration.

The copper chelating agents in current use include penicillamine, trientine and dimercaprol. These agents are used largely to treat Wilson disease, the complications of which are caused by excessive body copper accumulation. Dimercaprol (also known as British anti-Lewisite [BAL]) must be given intravenously and is generally used only for acute or advanced symptomatic Wilson disease. It is also effective in lowering levels of other heavy metals including arsenic and mercury. Penicillamine and trientine are orally available and are the mainstays of prevention and therapy of Wilson disease. Trientine is generally better tolerated than penicillamine, which has many difficult side effects including acute liver injury. Nevertheless, penicillamine appears to be more effective in the initial management of symptomatic Wilson disease and is preferred as a first line therapy. Zinc is also used to treat Wilson disease, but it appears to act by inhibition of absorption of copper from the diet rather than chelation of copper from serum or tissue.

The lead and other heavy metal chelators include succimer (dimercaptonol), dimercaprol (BAL), and ethylenediaminetetraacetic acid (EDTA). Succimer is orally available and appears to be more effective and better tolerated that the other therapies, which require intravenous administration. These agents are also used for arsenic, mercury and cadmium poisoning.

The chelating agents are rare causes of liver injury, the only agent convincingly linked to causing idiosyncratic acute liver injury with jaundice being penicillamine which usually causes of an immunoallergic, mostly cholestatic hepatitis with a short incubation period.

The following chelating agents are discussed individually or jointly.

1. Arsenic Chelators. They include Dimercaprol, Copper Chelators (for Wilson Disease),Dimercaprol,Penicillamine,Trientine and Zinc.

2. Iron Chelators. Such as Deferasirox, Deferiprone, and Deferoxamine.

3. Lead Chelators. Just like Dimercaprol, EDTA, Succimer.

4. Mercury Chelators. For example Dimercaprol.

The below information is collected from Wikipedia.

Chelation /ˈkiːˌleɪˈʃən/ is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central atom. These ligands are called chelants, chelators, chelating agents, or sequestering agents. They are usually organic compounds, but this is not a necessity, as in the case of zinc and its use as a maintenance therapy to prevent the absorption of copper in people with Wilson's disease.

Chelation is useful in applications such as providing nutritional supplements, in chelation therapy to remove toxic metals from the body, as contrast agents in MRI scanning, in manufacturing using homogeneous catalysts, in chemical water treatment to assist in the removal of metals, and in fertilizers.

A heterocyclic ring compound that can attract and hold a metal ion. Chelating agents are used to remove traces a metals in solutions, such as Zinc, Iron, Copper, Manganese, and Cobalt. They are added to detergents to minimize and precipitation or discoloration caused by unwanted metal ions. Chelating agents are also used in water softeners. Examples of chelating agents are ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid, n-hydroxyethylethylenediaminetriacetic acid (HEDTA), hemoglobin, Chlorophyll, as well as several simple organic acids like Oxalic acid, Malic acid. Rubeanic acid and Citric acid.

Resource from Wikipedia is Ended here.

About the research about the reaction of Chelating agent, you can find it here.

Chelating agents have many medical applications and Industrial and agricultural applications.

It can be used as Nutritional supplements.Ferrous bis-glycinate is an example of one of these compounds that has been developed for human nutrition.Then, you can find Chelating agents in Dentin adhesives. So it can be used in Dental and oral application.It is also used as Heavy-metal detoxification in Chelation therapy.In Other medical applications Chelation in the intestinal tract is a cause of numerous interactions between drugs and metal ions.

In industrial and agricultural applications. Chelating agents are used as Catalysis, Water softening, and Fertilizers. If you want to know the details, just contact us. We have professional R&D team support.

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